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 What causes depression and what are the symptoms? Depression, also known as clinical depression or major depressive disorder, occurs when you feel sad and hopeless on most days. This state of mind, which can last from two weeks to months, usually leads to lack of interest in hobbies and normal activities, weight loss or gain, insomnia or sleeping too much, fatigue and low energy levels, feelings of worthlessness and guilt and suicidal thoughts or actions in severe cases. While the exact causes of depression are not known, doctors believe that it’s due to imbalances in certain brain chemicals called neurotransmitters that help regulate our moods and emotions. Some Causes Of Depression The following is a list of potential causes of depression. There are, of course, more than just these. However, these seem to be some of the most common reasons for Depression. People with a family history of depression have an increased risk of developing it themselves. Genetics also play an importan...